Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
First Affiliated Hospital of Chongqing Medical University
Age
12–18
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
FEDN-MDD：
1. Age 12-18 years
2. Meet the diagnostic criteria for MDD according to the DSM-5
3. First-episode and drug-naive
4. HAMD-17 score \> 17
TRD:
1. Age 12-18 years
2. Meet the diagnostic criteria for MDD according to the DSM-5
3. HAMD-17 score \> 13
4. Currently or previously taking a standard therapeutic dose of antidepressant for at least 6 weeks, and they had at least one historical failure to an antidepressant (reduction in depressive symptoms \<50%)
HC:
1. age 12-18 years
2. HAMD-17 score \< 7
3. HCs without a personal history of a mental illness or family history in a first-degree relative
You may not be if
FEDN-MDD、TRD：
1. the presence or past history of severe medical, neurological or psychiatric disorders (other than MDD in patients)
2. anxiety comorbidity was not considered an exclusion criterion provided that MDD was the main diagnosis and the primary reason for seeking assistance
3. substance abuse, head trauma, or loss of consciousness
4. Chronic physical diseases that significantly affect peripheral metabolism or neurological function
5. Pregnant and lactating women
HC:
1. the presence or past history of severe medical, neurological or psychiatric disorders
2. substance abuse, head trauma, or loss of consciousness
3. Chronic physical diseases that significantly affect peripheral metabolism or neurological function
