Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly

Inclusion Criteria

• •Pathologically proven diagnosis of squamous cell carcinoma of the oropharynx (tonsil, base of tongue, soft palate, or oropharyngeal walls)
• •Patients must have clinically or radiographically evident measurable disease at the primary site or at nodal stations.
• •P16-positive based on local site immunohistochemical tissue staining
• •Clinical stage T1-3, N1-2, M0 (AJCC, 8th ed.)
• •Age ≥ 65.
• •Normal organ and marrow function within 14 days prior to registration defined as follows:
• •Absolute neutrophil count ≥ 1,500/mcL
• •Platelets ≥ 100,000/mcL
• •Hemoglobin ≥ 8.0 g/dL
• •Total bilirubin ≤ 1.5× institutional upper limit of normal (ULN)
• •AST(SGOT) or ALT(SGPT) ≤ 3.0 × institutional ULN
• •Serum creatinine ≤ 1.5× ULN