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Application of Concentrated Growth Factors in Alveolar Ridge Preservation | Clinical Trials | Clareo Health

RECRUITINGNA

Application of Concentrated Growth Factors in Alveolar Ridge Preservation

Study on the Effect of Concentrated Growth Factor in Promoting the Regeneration and Preservation of Soft and Hard Tissues

NCT06308536•The Fourth Affiliated Hospital of Zhejiang University School of Medicine

View on ClinicalTrials.gov

Summary

To explore the role of CGF in the regeneration or preservation of soft and hard tissues during tooth extraction site preservation surgery.

Detailed Description

A prospective, randomized controlled trial is designed to explore the role of CGF in the regeneration or preservation of soft and hard tissues in extraction site preservation. Using random number table, 20 patients were randomly divided into 4 groups using different filling materials in the extraction socket and materials for the wound sealing. Group A (5cases): bone powder + collagen membrane; Group B (5 cases): bone powder + collagen membrane + CGF membrane; Group C (5 cases): bone powder mixed CGF gel + collagen membrane + CGF membrane; Group D (5 cases): bone powder + CGF membrane. Extraction and site preservation surgery were performed by the same physician and clinical follow-up was more than 6 months after surgery. The four groups will be compared on several variables, including the changes in pain score, Landry wound healing index, membrane exposure area, keratinized gingival width, buccolingual gingival width, alveolar crest width and height.

Eligibility

Age

25 - 45 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Voluntarily participate in this trial and sign a written informed consent; Patients aged 25 ≤ age ≤ 45 years; The combination of intraoral and imaging examinations confirms that the affected tooth has no preservation value, requires tooth extraction, and the patient is willing to use site preservation; No progressive periodontal disease or acute apical periodontitis in the affected teeth; No long-term history of oral bisphosphonates; Non smoking patients； No systemic diseases such as diabetes and hypertension.

Exclusion Criteria

•Patients who have difficulty tolerating surgery; Patients under 25 years old or above 45 years old; The whole body is accompanied by hypertension, diabetes and other serious systemic diseases, which need to be controlled by drugs; Patients who take oral medication that affects bone metabolism for at least one month due to the need for disease treatment; Patients who take medication that may affect platelet function was used within 3 months due to the need for disease treatment; Patients unable to undergo X-ray imaging examination due to pregnancy or preparation after site preservation surgery; Patients who Smoke; The apical and periodontal inflammation is in the acute phase (purulent phase) Regular follow-up or follow-up for more than 6 months is not allowed

Locations (1)

The Fourth Affiliated Hospital Zhejiang University School of Medicine

Yiwu, Zhejiang Procince, China

Key Dates

Start Date

May 9, 2023

Primary Completion Date

October 1, 2024

Completion Date

April 1, 2025

Last Updated

March 13, 2024

Enrollment

ESTIMATED participants

Conditions

Alveolar Ridge PreservationConcentrated Growth Factor

Interventions

bone powder + collagen membrane

PROCEDURE

bone powder + collagen membrane + CGF membrane

PROCEDURE

bone powder mixed wih CGF gel + collagen membrane + CGF membrane

PROCEDURE

bone powder + CGF membrane

PROCEDURE

Contacts

Genying Zhuang, Master

CONTACT

13758195143 20918620@zju.edu.cn

Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation

NCT07242313

Alveolar Ridge PreservationPost Extraction Alveolar Bone Resorption

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RECRUITINGNA

Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?

NCT06275789

Alveolar Ridge PreservationDental Extraction+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 13, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Application of Concentrated Growth Factors in Alveolar Ridge Preservation

Inclusion Criteria

Exclusion Criteria

Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation

Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?

Influence of Various Healing Intervals on Alveolar Ridge Preservation Using Demineralized Dentin Graft: A Randomized Clinical Trial

Alveolar Ridge Preservation: Biologically-oriented Alveolar Ridge Preservation Vs Modified Periosteal Inhibition

Bovine Bone With or Without Concentrated Growth Factor in the Treatment of Chronic Periodontitis

Alveolar Ridge Preservation Versus Spontaneous Healing