A depressive episode according to Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria in the course of MDD with:
* HDRS score \> 17
* Age 18-65 years;
* In treatment with TSD+LT
Signed informed consent, able to understand, speak and write the national language
You may not be if
History of bipolar disorder, schizophrenia, schizoaffective disorder, psychosis not otherwise specified; anorexia or bulimia nervosa;
Taking following medications: antipsychotics, anticonvulsants, mood stabilizers; stimulants
Active infection requiring antibiotics therapy;
Immunosuppressed patient or other chronic diseases
Signs of active infection requiring treatment
Use of anti-inflammatory medication on a regular basis for a chronic inflammatory/autoimmune Disorder. Forbidden treatment: corticosteroids, Non Steroidal Anti-inflammatory Drugs, immunosuppressant IV-Ig based treatment
Ongoing fever, infection treated by antibiotics or uncontrolled diabetes type I or II;
Existing cancer or history of cancer in the last 5 years (except skin epidermoid cancer or in-situ cervix cancer);
Known HIV infection or clinically manifest Acquired Immune Deficiency Syndrome (AIDS), Parkinson's or Alzheimer's disease, or any other serious condition likely to interfere e with the conduct of the trial;
Aneurysm clip
Implanted neural stimulator
Implanted cardiac pacemaker or auto-defibrillator
Cochlear implant
Ocular foreign body (e.g., metal shavings)
Any implanted device (pumps, infusion devices, etc)
Shrapnel injuries
Clareo Health | Immune Activation, Neural Plasticity and Depression
