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Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response. Light, and particularly blue light, can stimulate alertness, attention and cognition through modulation of anatomical targets which are common to the vagal afferent network. This project aims at understanding how exposure to blue enriched light may influence VNS effects in patients with refractory epilepsy by exploring the modulation of a series of biomarkers of VNS action. This could possibly lead to new therapeutic strategies to increase efficacy of VNS.
Age
18 - 60 years
Sex
ALL
Healthy Volunteers
Yes
Cliniques Universitaires Saint Luc
Woluwe-Saint-Lambert, Belgium
Start Date
July 1, 2023
Primary Completion Date
July 1, 2023
Completion Date
April 1, 2026
Last Updated
September 10, 2025
34
ESTIMATED participants
electroencephalography, electrocardiogram, pupillometry, evoked potentials, light administration
OTHER
transcutaneous vagus nerve stimulation, electroencephalography, pupillometry, electrocardiogram, light administration
OTHER
Lead Sponsor
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
NCT06425029
NCT05019885
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