NIDCD Otolaryngology Clinical Protocol Biospecimen Bank

Study Description: National Institute on Deafness and Other Communication Disorders (NIDCD) investigators are studying the natural history and treatment of diverse conditions affecting hearing, balance, smell, taste, voice, speech and language at the National Institutes of Health (NIH). These studies require the collection of biospecimens for research purposes. Objectives: Primary: To create a biorepository of diseased and normal tissue specimens for research purposes. The samples will be obtained: * From surgical waste materials from participants of all ages in NIH protocols who have hearing, balance, smell, taste, voice, speech and language disorders. * Participants aged 3 and older may have collection of blood, saliva, and/or oral swabs. * Participants aged 18 and older, may undergo oral mucosal biopsies and skin biopsies and nasal secretion collection. Secondary: The specimens may be shared with other approved protocols or may be used under this protocol to conduct analysis of cellular, molecular, genetic and genomic biology of normal processes and disorders. These laboratory studies may support development of future protocols that include new therapeutic agents, novel treatment approaches, and new prognostic and diagnostic models for subjects with disorders of the head and neck affecting human communication. Endpoints: The primary endpoint of this study is the creation of a NIDCD biorepository from both surgical waste material and collected blood, saliva, oral swabs, nasal secretions, oral mucosa biopsy and skin biopsy specimens.