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COMPLETEDPHASE3

Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste

The Clinical Investigation of Stannous Fluoride Containing Toothpaste Compared to Colgate Cavity Protection Toothpaste in Reducing Plaque and Gingivitis - a Six-month Study in California

NCT06300866•Colgate Palmolive

View on ClinicalTrials.gov

Summary

The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of product use.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Potential subjects must meet all of the following criteria
•Subjects, ages 18-70, inclusive
•Availability for the six-month duration of the clinical research study
•Good general health
•Initial gingivitis index of at least 1.0 as determined by the use of the Loe-Silness Gingival Index
•Initial plaque index of at least 1.5 as determined by the use of the Quigley-Hein Plaque Index
•Signed Informed Consent Form

Exclusion Criteria

•Presence of orthodontic appliances
•Presence of partial removable dentures
•Tumor(s) of the soft or hard tissues of the oral cavity
•Moderate and/or advanced periodontal disease, rampant caries, or any condition that the dental examiner considers exclusionary from the study
•Five or more carious lesions requiring immediate restorative treatment
•Antibiotic use any time during the one-month period prior to entry into the study -Participation in any other clinical study or test panel within the one month prior to entry into the study
•Dental prophylaxis during the past two weeks prior to baseline examinations
•History of allergies to oral care/personal care consumer products or their ingredients -On any prescription medicines that might interfere with the study outcome
•An existing medical condition that prohibits eating and/or drinking for periods up to 4 hours
•History of alcohol and/or drug abuse
+1 more criteria

Locations (1)

Loma Linda University School of Dentistry

Loma Linda, California, United States

Key Dates

Start Date

August 18, 2020

Primary Completion Date

March 8, 2021

Completion Date

March 8, 2021

Last Updated

March 8, 2024

Enrollment

ACTUAL participants

Conditions

GingivitisPlaque, Dental

Interventions

Test

DRUG

Control

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 8, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste

Inclusion Criteria

Exclusion Criteria

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