NWRD08 DNA Plasmid for HPV-16 and/or HPV-18 Related Cervical HSIL

Exclusion Criteria

• •1. Microscopic or gross evidence of adenocarcinoma-in-situ (AIS), high grade vulvar, vaginal, or anal intraepithelial neoplasia or invasive cancer in any histopathologic specimen at screening;
• •2. Pregnant, breastfeeding or considering becoming pregnant during the study;
• •3. Administration of any non-live vaccines within 2 weeks prior to the first NWRD08 administration;
• •4. Administration of any live vaccines within 4 weeks prior to the first NWRD08 administration;
• •5. Treatment for cervical HSIL within 4 weeks prior to the first NWRD08 administration;
• •6. Any metallic implants/implanted electric devices around the intended sites of electroporation (deltoid muscles);
• •7. Participated in another clinical trial or was under observation in another clinical trial within 30 days prior to screening;
• •8. Continuous (more than 1 week) glucocorticoid therapy (dose equivalent to prednisone \> 10 mg/ day) within 30 days prior to screening, except hormone replacement therapy, intratracheal, ocular and topical administration;
• •9. A history of immune deficiency or autoimmune diseases (e.g., rheumatoid joint disease, systemic lupus erythematosus, multiple sclerosis, etc.);
• •10. Current or intended use of disease-modifying antirheumatic drugs (e.g., azathioprine, cyclophosphamide, cyclosporin and methotrexate) and biologic drugs (e.g., infliximab, adalimumab and etanercept);
• •11. Continuous (more than 1 week) use of immunosuppressive agents. (e.g., cyclosporin, tacrolimus, azathioprine, 6-mercaptoputine and antilymphocyte globulin, etc.);
• •12. Patients with a history of solid organ or bone marrow transplantation;
• •13. With uncontrolled severe infection (\> grade 2 NCI-CTCAE adverse events, version 5.0);
• •14. Patients with a history of human immunodeficiency virus (HIV) infection or carriers of syphilis;
• •15. Patients who are found to have active zoster virus infections;
• •16. Patients with serious other organ dysfunction or cardiopulmonary diseases;
• •17. Epilepsy that requires treatment with medication (e.g. steroids or antiepileptic drugs);
• •18. Had or currently has other malignancies (with the exception of adequately treated and completely cured ductal carcinoma in situ of the breast, carcinoma in situ of the cervix, basal cell carcinoma of the skin, superficial bladder tumor, or any malignancy that was cured more than 5 years before study entry);
• •19. A known history of albumin allergy, or severe allergy, or allergic disease, or allergic constitution, or severe iodine contrast allergy, meeting any of these criteria;
• •20. Patients with clinically significant heart disease or medical history;
• •21. Severe mental illness;
• •22. A history of drug or alcohol abuse;
• •23. Pregnant or lactating women, or women of childbearing age with positive blood pregnancy tests, or women of reproductive age and their spousal not willing to use contraception during and up to 6 months following completion of the study;
• •24. Patients deemed by the investigator to be ineligible for this clinical trial.