GI Alpha-Gal Study

Exclusion Criteria

• •The subject has health conditions that would pose a significant threat in the face of anaphylaxis or treatment for anaphylaxis (e.g., cardiac disease, unstable angina pectoris, arrhythmias).
• •The subject is allergic to mannitol.
• •If female, the subject is pregnant.
• •The subject has a history of chronic GI conditions, including inflammatory bowel disease, celiac disease, chronic pancreatitis with continued symptoms (experience moderate-severe abdominal pain, diarrhea, or nausea/vomiting that occur more frequently than once weekly)
• •The subject has diarrhea (one or more loose stools that conform to the container), moderate to severe abdominal pain, or vomiting within 10 days prior to the challenge.
• •The subject has a history of severe allergic reaction on mammalian meat ingestion (respiratory distress, chest pain or cardiopulmonary compromise)
• •The subject is unwilling to receive intramuscular epinephrine.
• •The subject is anticipated to use omalizumab within 6 months of enrollment.
• •The subject is anticipated to use systemic steroids within 28 days of food challenge.
• •The subject is anticipated to use leukotriene modifier within 14 days of food challenge.
• •The subject is unable to not use nonsteroidal anti-inflammatory drugs for 14 days prior to challenge.
• •Known conditions that are contraindications to transnasal endoscopy, or in the opinion of the investigator any condition that would interfere with the study objectives.
• •History of head and neck malignancy or anatomical deformities of the nasopharynx
• •Severe anxiety