Efficacy of Face Mask in Reducing Respiratory Allergic Symptoms in Birch-allergic Subjects in ALYATEC Exposure Chamber

Inclusion Criteria

• •Subjects who signed the written informed consent,
• •Subjects covered by health social identification number,
• •Subjects able to understand and complete study-related procedures,
• •Subjects reported history of symptomatic birch pollen allergen-triggered asthma (GINA1) with associated allergic rhinitis,
• •Positive skin prick test (SPT) with cat hair extract with mean wheal diameter ≥ 5 mm compared to negative control (NaCl reaction \< 2 mm),
• •Positive sIgE tests for birch tree pollen and Bet v 1 (≥0.7 kUa/L),
• •Subjects with FEV1 ≥ 70% predicted at screening and before allergen exposure,
• •Subjects with at least one drop in FEV1 ≥20% during the 1-hour baseline exposure
• •ACT≥ 20,
• •Women of childbearing potential with a negative pregnancy test throughout the study period and a highly effective contraception: oral contraceptives, condom with spermicide, intrauterine device, bilateral tubal ligation, vasectomized partner.