Using Low Intensity Focused Ultrasound to Modulate Deep Brain Areas for Tremor Control in Parkinson's Disease Patients.

Exclusion Criteria

• •Atypical Parkinsonism
• •History of essential tremor
• •Dementia preventing informed consent
• •Change in Parkinson's medication with the last 2 weeks
• •Neurological disease other than PD, including Alzheimer's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, a brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma
• •Unstable medical conditions or serious disease/conditions (e.g., cancer undergoing active treatment, poorly controlled diabetes)
• •Concurrent treatment for PD with Duodopa
• •Concurrent treatment for PD with deep brain stimulation (DBS)
• •Thickness of the temporal bone \< 7 mm
• •Individuals should also not participate if they have any of the following contraindications for undergoing fMRI scanning:
• •Cardiac pacemaker, wires, or defibrillator
• •Metal in eye or orbit, including the history of any eye injury involving metal fragments and increased risk due to (history of) working as a metal worker (grinding, machining, or welding)
• •Ferromagnetic aneurysm clip
• •Possibility of pregnancy
• •Artificial heart valve
• •Ear or eye implant, including cochlear implant
• •Brain aneurysm clip
• •Implanted drug infusion pump
• •Electrical stimulator to nerves or bones
• •Coil, catheter, or filter in any blood vessel
• •Orthopedic hardware (artificial joint, plate, screw, rod)
• •Other metallic prostheses
• •Shrapnel, bullets, or other metal fragments
• •Surgery, piercings or tattoos (including tattooed eyeliner) in the last six weeks
• •Medication releasing skin patches (i.e. nicotine, birth control, nitroglycerine)
• •History of claustrophobia