18 to 70 years old at the time of signing the Informed Consent Form (ICF).
Diagnosed as SLE/Immune-Mediated Necrotizing Myopathy (IMNM)/Neuromyelitis Optica Spectrum Disorders (NMOSD)/Multiple Sclerosis (MS)/Myasthenia Gravis (MG)/Systemic Sclerosis (SSc) according to recognized diagnostic criteria for at least 6 months.
Remains disease active or relapses after treatment with standard of care therapy for at least 8 weeks with the dose stable for more than 2 weeks; patients should have been treated with at least two immunosuppressants (including immunosuppressants, biologics, and disease-modifying drug (DMD) ).
Adequate bone marrow, coagulation, cardiopulmonary, liver and renal function.
You may not be if
Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV), Treponema Pallidum (TP) positive, Cytomegalovirus (CMV) DNA positive, Epstein-Barr Virus (EBV) DNA positive.
Uncontrolled active infection.
Live vaccine injection within 4 weeks prior to signing the ICF.
Major organ transplantation history or bone marrow/hematopoietic stem cell transplantation history.
Severe cardiovascular diseases within the past 6 months prior to screening.
≥ Grade 2 bleeding within the past 30 days prior to screening, or requiring long-term anticoagulants treatment.
Inadequate washing time for previous treatment.
Previously treated with CAR-T cell products or genetically modified T cell therapies.
Pregnant or lactating women.
Severe central nervous system diseases or pathological changes.
Malignancy history within 5 years prior to signing the ICF.
