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Clinical Research Study to Assess the Efficacy of Two Brushing Regimens

Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Dental Plaque and Aid of Gum Problems

NCT06240481•Colgate Palmolive

Summary

The objective of this twelve-week clinical research study is to assess the efficacy of two brushing regimens: 1) toothpaste with mouthwash containing sodium fluoride/zinc and manual toothbrush as compared to 2) regular fluoride toothpaste and manual toothbrush in the reduction of dental plaque and aid of gum problems.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Signed Informed Consent Form.
•Male and female subjects aged 18-70 years, inclusive.
•Availability for the twelve-week duration of the clinical research study.
•Good general health based on the opinion of the study investigator
•Minimum of 20 permanent natural teeth (excluding third molars).
•Initial gingivitis index of at least 1.0 as determined by the use of the Loe and Silness Gingival Index.
•Initial plaque index of at least 1.5 as determined by the use of the Quigley and Hein Plaque Index (Turesky Modification)

Exclusion Criteria

•Presence of orthodontic appliances.
•Presence of partial removable dentures.
•Tumor(s) of the soft or hard tissues of the oral cavity.
•Moderate and/or advanced periodontal disease, rampant caries, or any condition that the dental examiner considers exclusionary from the study.
•Five or more carious lesions requiring immediate restorative treatment.
•Antibiotic use any time during the one-month period prior to entry into the study. -Participation in any other clinical study or test panel within the one month prior to entry into the study.
•Dental prophylaxis during the past two weeks prior to baseline examinations.
•History of allergies to oral care/personal care consumer products or their ingredients. -On any prescription medicines that might interfere with the study outcome.
•An existing medical condition that prohibits eating and/or drinking for periods up to 4 hours.
•History of alcohol and/or drug abuse.
+1 more criteria

Locations (1)

Clinica Dental Dr. Sitges

Manresa, Spain

Key Dates

Start Date

September 23, 2024

Primary Completion Date

December 21, 2024

Completion Date

December 21, 2024

Last Updated

February 6, 2026

Enrollment

ACTUAL participants

Conditions

Dental PlaqueGingivitis

Interventions

Test Regimen

DRUG

Control Regimen

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 6, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Clinical Research Study to Assess the Efficacy of Two Brushing Regimens

Inclusion Criteria

Exclusion Criteria

NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery

Lactoferrin-Based Oral Care for Periodontal Health in Pregnancy

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