Basic and Clinical Studies of Levodopa/Carbidopa/Entacapone in the Treatment of Early Parkinson's Disease

Exclusion Criteria

• •Diagnosis of atypical Parkinsonian syndrome, vascular Parkinsonism or drug-induced Parkinsonism.
• •History of surgery within 6 months.
• •Alcoholism, drug abuse, or severe cognitive impairment (including severe Alzheimer's disease)
• •Psychiatric illness, epilepsy, pregnancy and breastfeeding, and clinically significant concomitant illnesses
• •Participation in another clinical trial within 2 months.
• •With dyskinesia.
• •Any other condition that, in the opinion of the investigator, makes them ineligible for enrolment.