Tacrolimus Minimization in Kidney Transplant Recipients Selected According to the AGORA Algorithm for Their Low Immunological Risk and Medium-term Graft Failure

Inclusion Criteria

• •First kidney transplantation
• •Living or brain death or
• •Donation after circulatory death (Maastricht 3) donor,Compatible for ABO group with the donor,
• •cPRA (Panel Reactive Antibody Calculated ) (or TGI: Incompatible Graft Rate )\<20% on the day of the transplantation and no DSA (MFI \<500) at pre transplant and at the time of the inclusion at one-year post transplantation (between 350 and 515 days after the transplantation.
• •Eplet Mismatchs \<= 14
• •Normal or IFTA 1-2 histology on one-year surveillance biopsy.
• •Patient insured under a health insurance scheme, according to national regulation.
• •Patient (of childbearing age) with effective contraception.
• •Patients treated with Tacrolimus (Prograf® or Advagraf®) and MMF / MPS (Mycophenolate Sodium) +/- Corticosteroid (CS)