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Plasma Dilution and Infusion to Improve Cognition in Mild Cognitive Impairment (MCI)

NCT06234436·1 site·ClinicalTrials.gov

What this study is about

Take this into the appointment.

Saves the questions and what to expect into your notes, next to the visit they belong to.

Keep this study

Lead

Oslo University Hospital

With

Impetus Grants (EIN: 87-1540960)
The National Association for Public Health, Norway
Vestre Viken Hospital Trust

Repeated plasma exchanges will be conducted, and cognitive outcomes will be measured before and after the intervention.

Age

Any age

Sex

ALL

Healthy volunteers

Not accepted

You may be eligible if

Clinical diagnosis of Alzheimer's Disease
MoCA score \< 27 and \>17
Able to give informed consent as judged by the doctor setting the AD diagnosis and study doctor.
At least one biomarker of the AT(N)-classification system supporting the diagnosis
Expected to live more than five years at inclusion by the study doctor.

You may not be if

Known IgA deficiency
Known severe protein S depletion
Previous severe allergic reaction after transfusion of a blood product
Known heart failure
Known liver failure
Known kidney failure
Previous cancer \<10 years.
Not deemed able to participate by the study staff
Other severe chronic diseases, interfering with the TPE-procedure
Ongoing infections
Other unresolved medical conditions
Known coagulopathies
Fulfilling ICD-10 criteria for dementia at baseline, as evaluated by the evaluating physician.
Peripheral veins not expected to be suitable for repeated venous access procedures.

The record

StatusUnknown

PhaseEarly phase 1

Taking part10

StartedDec 2023

UpdatedJan 31, 2024

Conditions

Alzheimer Disease

Where1

Oslo University Hospital
Oslo, Norway