Efficacy and Safety of Linperlisib in Relapsed/Refractory Large Granular T Lymphocytic Leukemia

Exclusion Criteria

• •History of other lymphoproliferative neoplasms
• •Had malignant tumor within 5 years before enrollment, exclusive of cured basal or squamous cell skin cancer, superficial bladder cancer, prostate intraepithelial tumor, cervical carcinoma in situ or other indolent tumors
• •Previously received organ or stem cell transplantation
• •Patients with active infection within 2 weeks before giving the first dose of medication
• •Patients with HBV, HCV, HIV or other infections that require treatment
• •History of immunodeficiency, or congenital immunodeficiency disorders
• •Any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study, including clinically significant cardiac diseases, refractory hypertension, metabolic disorders and other diseases that seriously affect the function of the gastrointestinal tract.
• •Abnormal liver function: two consecutive examinations with an interval of ≥1 week suggest that ALT and AST are 2.5 times higher than the upper limit of normal values
• •Renal impairment: creatinine clearance \<30ml/min
• •History of mental illness
• •History of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-related pneumonia, severe impairment of lung function, etc.
• •Received attenuated vaccine 4 in weeks before enrollment
• •Participation in another clinical trial within 4 weeks before the start of this trial
• •Have an allergy to Linperlisib or any other part of this medicine.
• •Pregnant or breast-feeding patients
• •Patients considered to be ineligible for the study by the investigator for reasons other than the above