Study to Evaluate Safety and Immunogenicity of a Prime-Boost Regimen of rVSV-Nipah Virus Vaccine Candidate PHV02 in Healthy Adult Subjects

Exclusion Criteria

• •Prior infection with Nipah virus, related Henipaviruses or Ebola virus
• •Prior infection with vesicular stomatitis virus (VSV)
• •Received VSV-vectored vaccine or Ebola vaccine
• •BMI \< 18.5 or ≥ 35
• •Healthcare worker with direct physical contact with patients
• •Childcare worker in direct contact with children 5 years old or younger
• •Household contact who is immunodeficient, or on immunosuppressive medication
• •Hands-on food preparation job
• •Primary care or treatment of cattle, horses, or swine
• •Hepatitis B, hepatitis C, HIV-1, HIV-2, diabetes, atopic dermatitis (eczema), chronic inflammatory disease, autoimmune or autoinflammatory disorder, malignancy, chronic or active neurologic disorder
• •History of severe reactions to any vaccine or history of severe allergies
• •Receipt of investigational product up to 30 days prior to, or planned receipt within 196 days after randomization, or ongoing participation in another interventional clinical trial.
• •Receipt of licensed non-live vaccines within 14 days of planned study immunization (30 days for live vaccines) or planned receipt of non-live or live vaccine within 60 days after first study immunization (30 days after the 2nd vaccination).
• •Known allergy to components of PHV02
• •Injection sites obscured by tattoos or physical condition
• •Significant psychiatric or medical condition or laboratory abnormality on screening
• •History of Guillain Barre Syndrome or any chronic or acute neurological disorder
• •Alcohol or illicit drug abuse within past 5 years
• •Pregnant or lactating female
• •Administration of blood or IgG within 120 days preceding study
• •History of blood donation within 60 days of study
• •Unwilling to undergo diagnostic evaluation of rash (skin biopsy, if indicated) or joint symptoms (arthrocentesis if indicated by joint effusion), in both cases if acceptable to subject
• •Elective surgery planned during the study period