Assessment of Healing Properties Using Hyaluronic Acid Topical Application in Parasymphyseal Fracture Fixation: A Randomized Clinical Trial

Patients of both groups will be subjected to: 1. Clinical assessment including case history including personal data,medical,surgical history and family history 2. Radiographic assessment includes preoperative digital panomora to evaluate fracture and to conclude presence or absence of any foreign body or pathological pathosis. 3. Signing the informed consent will be done after explaining surgical procedure. All the patients will be nasally intubated, scrubbed and draped in the standard manner, followed by intra-oral and extra-oral povidone-iodine (Betadine)swabbing. Local anesthesia containing vasoconstrictor will be injected in the vestibule Incision at lower anteriors will be done in the mucosa in a curvilinear fashion 10-15mm away from the attached gingiva, the incision distal to the canine will be 5 mm from the attached gingival to be superior to the mental nerve. Submucosal dissection will be done to expose the mentalis muscle, followed by mucoperiosteal flap elevation till inferior border exposing the fracture line. The fracture segments will be reduced after curettage and removal of any debris. MMF will be done to ensure proper occlusion. Two four-hole titanium miniplates will be placed on inferior border and another one on superior border. For the intervention group: placement of hyaluronic acid paste will be carried over gel foam and placed between fractured segments before plate fixation. For the control group: no hyaluronic acid paste will be applied during fixation only gel foam between fractures segments without any additives. Suturing using 4-0 resorbable sutures will take place after MMF release in layers, anteriorly mentalis muscle will be closed first to prevent chin drooping followed by a continuous running closure of mucosa. Elastic dressing will be applied over chin region supporting the soft tissues and preventing hematoma formation. Post-operative care: Avoid traumatization of the surgical site. All patients will be instructed to apply ice packs over submental area for 15 minutes per hour for 24 hours postoperatively. All patients will be given postoperative medication as follows: Anti-inflammatory drug diclofenac potassium (Cataflam50mg)2tabletsevery8hoursforaweek to relieve pain Antibiotic drug Amoxicillin/clavulanic acid tablets (Hibiotic 1gm)1gm every 12 hours for 7 days -Benzethonium Chloride (Antiseptol mouthwash), starting from the day after the surgery 3 times daily for 10 days. Instruct the patient not to touch or manipulate the surgical area. No consumption of tobacco for one week postoperatively.