Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Bayer
Age
18–55
Sex
MALE
Healthy volunteers
Accepted
You may be eligible if
Capable of giving signed informed consent
Participant must be 18 or age of legal maturity to 55 years of age inclusive, at the time of signing the informed consent
Participants who are overtly healthy as determined by the investigator or medically qualified designee based on medical evaluation including medical history, laboratory tests, physical, cardiac, and neurologic examination
Body mass index (BMI) within the range \[18 - 30\] kg/m\^2 (inclusive), with bodyweight above/equal to 50 kg
Male
Study participants of reproductive potential must agree to use adequate contraception when sexually active during the study period and for at least 3 months after the last dose of study intervention, and refrain from donating sperm during this period
Participant must have venous access sufficient to allow blood sampling as required by the protocol
Participant must be willing to undergo multiple blood draws as required by the protocol
Participant must be willing to comply with dietary and fluid requirements during the treatment period (including abstaining from alcohol use)
Ability to understand and follow study-related instructions
You may not be if
Existing relevant diseases of vital organs (e.g., liver diseases, heart diseases, gastrointestinal diseases, interstitial lung disease), central nervous system (for example seizures) or other organs (e.g., diabetes mellitus)
Incompletely cured pre-existing diseases for which it can be assumed that the absorption, distribution, metabolism, elimination, and effects of the study intervention will not be normal
Any relevant diseases within 4 weeks prior to the first study intervention administration as judged by the investigator
A medical history of risk factors for Torsades de pointes (e.g., family history of long QT syndrome) or other clinically significant arrhythmias as judged by the investigator
Known history of hypersensitivity (or known allergic reaction) to BAY2927088-related compounds, or any components of the formulation
History of known or suspected malignant tumors
Participants with any type of psychiatric disorder, especially any mood disorders including medical history with suicidal ideation and/or suicide attempts, which may disable the participant to consent
Any condition which may result in longer than usual retention of urine or feces in the body, such as pronounced (less than one defecation in 3 days) constipation or symptomatic prostatic hypertrophy
Exposure to radiation for diagnostic reasons (except dental X-rays and plain X-rays of thorax and bony skeleton \[excluding spinal column\]), during work or during participation in a clinical study in the period of 1 year prior to screening
Participant will be excluded when he participated in another study with a radiation burden of 0.1 - 1 mSv (inclusive) in the period of 1 year prior to screening; 1.1 - 2 mSv (inclusive) in the period of 2 years prior to screening; 2.1 - 3 mSv (inclusive) in the period of 3 years prior to screening, etc. (add 1 year per 1 mSv)
