Age

8–21

Sex

ALL

Healthy volunteers

Not accepted

Age 8 -21 years old.
Diagnosis of Crohn's disease within 24 months
Elevation in objective inflammatory markers at enrollment: C-reactive protein (CRP), ESR, or fecal calprotectin
Active Crohn's disease, as defined by Pediatric Crohn's Disease Activity Index (PCDAI) ≥10.
Participant capable of giving informed consent, or if a minor the parent/guardian is capable of giving informed consent.

History of surgery for Crohn's disease.
Perianal disease as part of Crohn's disease phenotype.
Recent use of:
corticosteroids (within 4 weeks),
dose adjustment of immunomodulator (within 8 week)
azathioprine 4 weeks prior to study final visit (week 8)
start or adjust methotrexate 3 weeks prior to final study visit.
Prior use of biological medication
Prior treatment with EEN or other dietary therapy for Crohn's disease.
Prior treatment with antibiotics for Crohn's disease.
Known allergies to any of the food components in the smoothie.
Admission to hospital due to severity of Crohn's disease and associated symptoms.
Unwillingness to provide informed consent.

Reverse-Engineering of Exclusive Enteral Nutrition (RE-EEN) in Crohn's Disease: A Multi-Center Trial