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Evaluation of Atherosclerotic Carotid Plaque Stiffness by Shear Wave Elastography, Greyscale Median, Magnetic Resonance Imaging and Histopathological Analysis: Diagnostic Test Study
The goal of this prospective diagnostic accuracy cohort study is to compare the accuracy of carotid atherosclerotic plaques stiffness assessed by shear wave elastography (SWE) with greyscale median values (GSM), magnetic resonance imaging (MRI) and histopathological findings in patients with carotid atherosclerotic plaques causing stenosis above 50%, symptomatic or not. The main question it aims to answer is: is the plaque stiffness correlatable with GSM values, MRI findings or histopathological findings? Participants will be subjected to a vascular ultrasound study in which the SWE and GSM will be assessed. The second imaging modality for stenosis confirmation will be MRI and patients with confirmed symptomatic stenosis above 50% or assymptomatic stenosis above 70% will be considered for surgery intervention (endarterectomy or angioplasty). Patients that undergo endarterectomy will have the carotid plaques subjected to a histopathological study. The study will not arbitrate about the treatment decision.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Sao Paulo State University
Botucatu, São Paulo, Brazil
Start Date
March 1, 2023
Primary Completion Date
June 30, 2025
Completion Date
December 31, 2025
Last Updated
April 6, 2025
43
ESTIMATED participants
Vascular Ultrasound
DIAGNOSTIC_TEST
Shear Wave Elastography
DIAGNOSTIC_TEST
Greyscale Median
DIAGNOSTIC_TEST
Magnetic Resonance Imaging
DIAGNOSTIC_TEST
Histopathology
DIAGNOSTIC_TEST
Lead Sponsor
UPECLIN HC FM Botucatu Unesp
NCT06541691
NCT06253962
Data Source & Attribution
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