A Study of Axicabtagene Ciloleucel and Glofitamab as Second-Line Therapy for Relapsed or Refractory Patients With Large B Cell Lymphoma

Primary Objectives * To evaluate the safety of axicabtagene ciloleucel (axi-cel) and glofitamab as combination therapy in 2nd line LBCL participants * To evaluate the effect of axi-cel and glofitamab as combination therapy on the best complete response rate in 2nd line LBCL participants Secondary Objectives * To evaluate the effect of axi-cel and glofitamab as combination therapy on overall survival (OS) in 2nd line LBCL participants * To evaluate the effect of axi-cel and glofitamab as combination therapy on progression free survival in 2nd line LBCL participants * To evaluate the effect of axi-cel and glofitamab as combination therapy on best overall response rate in 2nd line LBCL participants Exploratory Objectives * Characterization of tumors via tumor profiling and antigen density measurement using flow cytometry at baseline * Characterization of genetic markers via tumor single cell (sc) multiome sequencing and whole exome sequencing (WES) at baseline * To study the kinetics of circulating tumor DNA (ctDNA) during study progression * To evaluate the development of anti-axi-cel antibodies during study progression * To evaluate the effect of glofitamab administration on T cell exhaustion during study progression