Age

50–any

Sex

ALL

Healthy volunteers

Not accepted

Men and women aged 50 and over
COPD stage 3 or 4 according to GOLD criteria
BMI \< 20 kg/m2 if \< 70 years old or \< 22 kg/m2 if ≥ 70 years old
Suspicion of sarcopenia marked by a score of 4 or more on the SARC-F questionnaire
Absence of severe COPD exacerbation for at least 3 months

Main respiratory disease other than COPD
Daily long-term use of systemic corticosteroids (\>6 months per year, whatever the dose)
Severe and end-stage renal insufficiency (creatinine clearance \<30ml/min)
Patient with severe hypotension, uncontrolled hypertension (at investigator's discretion)
Contraindication to L-citrulline intake: VKA and/or cancer chemotherapy
Osmotic diarrhoea
Severe and/or uncontrolled progressive pathology likely to be life-threatening
Psychiatric pathology (schizophrenia, dementia, severe bipolar/psychotic disorders, severe depressive syndrome)
Pacemaker or other implanted electronic device

Oral Citrulline Supplementation in COPD Patients With Malnutrition