Jesper H Brendel, MD.

CONTACT

Lead Sponsor

Central Denmark Region

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Age greater than or equal to 18 years.
•2. Medical history of COPD.
•3. Unable to give informed consent ("Inhabil" in Danish) based on the criteria below
•4. Respiratory acidosis with a PaCO2 of \> 6,0 kPa and a pH of \< 7,30.
•And one of the following:
•5. Respiratory rate of \> 25 per minute.
•6. Hypoxia with a PaO2 \< 7 kPa and/or a saturation \< 88% without oxygen administered.

•1. Upper gastrointestinal hemorrhage or vomiting.
•2. Anatomical abnormality that precludes the use of an oro-nasal interface.
•3. Suspicion of pneumothorax.
•4. Cardiac or respiratory arrest.
•5. Uncontrollable malignant arrhythmia.
•6. Refractory shock (systolic blood pressure \< 90 mmHg) despite fluids and/or vasoactive drugs given.
•7. Required orotracheal intubation.
•8. Suspected upper airway obstruction.
•9. No indication for life-prolonging treatment with NIV.