Finding studies
Finding studies
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Lead
National University Hospital, Singapore
With
Primary Objectives: As a preliminary Phase I trial, the primary objective of the study would be to evaluate the percentage change in prostate specific antigen (PSA) from baseline to 12 weeks. Secondary Objectives: 1. determine the proportion of patients achieving PSA response (≥ 50% reduction in PSA after 12 weeks of therapy). 2. evaluate the pharmacokinetics associated with the 500 mg dose of abiraterone acetate. 3. investigate the correlation between plasma exposure of abiraterone and CP-I or CP-III in order to support their utility as a biomarker of OATP1B1/1B3 function. 4. assess the pharmacodynamic effects of the reduced 500 mg dose on the maximal percentage change in serum androgens (dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), testosterone, androstenedione) from baseline.
Age
21–99
Sex
MALE
Healthy volunteers
Not accepted