Fecal Microbiota Transfer to Improve Diabetes Control Post-bariatric Surgery

Inclusion Criteria

• •Adult patients from 18-65 years old
• •T2D patients any severity of initial T2D disease before BS
• •Who underwent Bariatric surgery (BS) 1 to 5 years before (Roux-en-Y gastric bypass or sleeve, patients with pre-BS BMI≥35kg/m²)
• •Non-Diabetic remission (NDR) patients 1-year post-BS, defined as Hba1c\>6.5% and/or fasting glycaemia\>6.9mmol/l and/or receiving anti-diabetic drugs for at least 2 months. We will rather select patients with uncontrolled diabetes with Hba1c\>7% and willing to receive proton pump inhibitor (PPI)
• •Patient compliant to 1rd year follow-up post-BS (who came to at least 2 among the three routine care follow-up visits during the first year (i.e. 3, 6 and 12M)
• •Signature of the informed consent
• •Affiliated to a social security regime (except AME)
• •Age ≥ 18 years and \< 50 years
• •Lean individuals (18\<BMI\<25kg/m²)
• •Euglycemic: fasting glycemia \<6mmol/l; Hba1c \<5.9%
• •Healthy: no current drug prescription (except contraception or pain killers other than AINS)
• •Regular bowel movement in the morning defined as 1 stool/day at least
• •Signature of the informed consent
• •Subject with health insurance (except AME)