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RECRUITINGEARLY Phase 1NCT06190197

Prophylactic Antibiotics in Cystectomy With Diversion

Using a randomized 2 arm design, this study is being conducted to test for non-inferiority of no prophylactic antibiotic therapy versus the prophylactic oral antibiotic, nitrofurantoin, through compar...

Lead sponsor: University of Minnesota•1 U.S. locations•View source on ClinicalTrials.gov

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Contacts

Judith Graziano

CONTACT

612-625-7486 grazi005@umn.edu

Sponsors

Lead Sponsor

University of Minnesota

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Presence of muscle invasive bladder cancer and planning to undergo radical cystectomy with either ileal conduit or neobladder diversion.
•18 years of age or older

Exclusion Criteria

•Currently receiving antimicrobials for active infection
•Poor renal function with GFR \< 30 ml/min
•Allergy to nitrofurantoin and unable to take an alternative antibiotic (cephalexin, trimethoprim-sulfamethoxazole, or ciprofloxacin)
•Pregnancy
•Unable to provide Informed consent
•Prior pelvic radiation

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: November 17, 2025Terms

Trial snapshot

StatusRECRUITING

PhaseEARLY_PHASE1

Enrollment120

Start dateMay 2024

Last updatedNov 17, 2025

Condition

Muscle-Invasive Bladder Carcinoma Radical Cystectomy Ileal Conduit Neobladder Diversion

Locations shown

University of Minnesota

Minneapolis, Minnesota

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 17, 2025Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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