Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
LG Chem
Age
18–55
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Male or female, Ages 18 to 55, inclusive.
BMI 18.0 - 32.0 kg/m2, inclusive, at screening.
In good general health as determined by medical history, clinical laboratory assessments, vital sign measurements, 12-lead ECG results, and physical examination findings at screening.
Females of childbearing potential and males who agree to use contraception. Non-pregnant, non-lactating females who must have a negative pregnancy test at screening and check-in.
You may not be if
Significant history or indications of ill-health, as judged by the investigator.
Any surgical or medical condition(s) possibly affecting drug absorption, distribution, metabolism, and excretion.
eGFRcr of \<60 (mL/min)/1.73 m2 at screening.
alanine aminotransferase, aspartate aminotransferase, or total bilirubin ≥2 times the upper limit of normal at screening and check-in.
Used any prescription or over-the-counter medications (except acetaminophen \[Tylenol\] up to 2 g per day), including herbal or nutritional supplements, within 14 days before the first dose of study drug.
Consumed grapefruit or grapefruit juice, Seville orange or Seville orange-containing products (eg, marmalade), or caffeine- or xanthine-containing products within 48 hours before the first dose of study drug.
History of hypersensitivity to theophylline or other xanthines and tigulixostat.
