Electroencephalographic Changes in Nonconvulsive Children With Chronic Renal Disease

Aim of the study Evaluate electroencephalographic changes in children with chronic renal disease and nephrotic syndrome Patient and Method include : Methodology Subjects selected are divided into 3 groups A. Patient with chronic kidney disease under dialysis B. Patients with nephrotic syndrome * Patients in remission * Patients relapse C. Normal control group Detailed history including age, sex , residence ,complain, renal symptoms will be taken. Detailed examination, lab investigations, and treatment will be recorded Imaging ( EEG) , results of the three groups will be assessed and compared and lab investigation ( lipid profile of all patients) will be measured TYPE OF THE STUDY Observational study Sitting of the study Assiut University children hospital Inclusion criteria All children with chronic kidney disease and nephrotic syndrome Exclusion criteria * Newborn * Patients with genetic disease Neurological disorder Sample size Based on determining the main outcome variable, the estimated minimal required sample size is 102 patient (34 patient in each group).the sample was calculated using Gpower software 3.1.9.2.,based on the following assumptions: main outcome variable is the deference in the main value of relative power of delta band of patients with chronic kidney disease ,patients with nephrotic syndrome, and normal control group. based on clinical experience we expected to find large effect size difference between the 3 groups .main statistical test is independent t-test to detect the difference between the 3 groups Alpha=.05 Power=.95 Effect size=1.1 Statistical analysis All statistical analysis will be performed by SPSS version 20. Mean and standard deviation will be used for descriptive statistics . for quantitative data Ethical considerations: 1. risk-benefit ratio The EEG has been used for many years and is considered a safe procedure. The test causes no discomfort. The electrodes record activity. They do not produce any sensation. In addition, there is no risk of getting an electric shock. 2. confidenity Any data taken from the patient either from history the examination or the investigations will be very confidential 3. researsh statement Every patient subjected to this study will be informed about the procedure of the research 4. informed consent The aim of our investigation will be explained to all parents and informed written consent was taken as well • Other ethical concerns The research will be conducted only by scientifically qualified and trained personnel