Greater-Bay-Area Healthy Aging Brain Study (GHABS)

Inclusion Criteria

• •Age 55-90 years old (including 55 and 90 years old). However, people with autosomal dominant and other familial Alzheimer disease (FAD) are not limited by age.
• •The score of the Geriatric Depression Scale (GDS) is less than 6 points.
• •There is a caregiver who can maintain at least 10 hours of contact per week and can accompany volunteers to the test site for testing.
• •Visual and auditory acuity is sufficient for neuropsychological testing. (Including normal corrected vision and hearing)
• •Be in good health and are expected to be free of disease interference during the study.
• •Volunteers are not pregnant, lactating or have reproductive potential (that is, women must be two years after menopause or undergo sterilization surgery).
• •Willingness and ability to participate in longitudinal imaging studies.
• •A modified version of the Hachinski Ischemic scores less than or equal to 4.
• •Have completed grade 6 education or have good work experience (sufficient to rule out mental retardation).
• •Must be able to speak Mandarin fluently.
• •Willing to undergo multiple 3T MRI scans and at least two PET scans.
• •Agree to collect blood for genomic analysis (including GWAS sequencing and other analyses), AD risk and protective genes such as apolipoprotein E (APOE), klotho, etc., and biological sample storage.
• •Agree to collect blood for biomarker detection.
• •Agree to share genomic data and biomarker samples.