Periodontal Microbiota in Systemic Sclerosis

Exclusion Criteria

• •\- Subject under court protection
• •Subject under guardianship or curatorship
• •Pregnancy or breastfeeding
• •Impossibility to provide accurate information (emergency situation, comprehension difficulties…)
• •Subject currently involved in another clinical trial or in an exclusion period following participation in another clinical trial
• •Smoking (≥ 10 cigarettes per day)
• •Other associated systemic auto-immune disease (Sjögren syndrome with positive serum anti-SSA and/or anti-SSB auto-antibodies, systemic lupus erythematosus…)
• •Progressive chronic illness other than systemic sclerosis
• •Acute infection at inclusion
• •Progressive cancer or cancer diagnosed within 2 years prior to the study
• •Ongoing antibiotic and/or antifungal treatment or within 3 months prior to inclusion
• •Probiotics and/or prebiotics intake within 3 months prior to inclusion
• •Oral antiseptics within the week before inclusion (chlorhexidin mouthwashes…)
• •Risk of infective endocarditis
• •Corticosteroids ≥10 mg/day and/or proton pump inhibitors within 3 months prior to inclusion
• •Previous hematopoietic stem cell transplantation
• •Another cause of skin sclerosis (radiotherapy of the orofacial area…)
• •Periodontal specialized treatments, root and/or periodontal surgical treatment and/or subgingival instrumentation within the year before inclusion