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Value of Intravenous Fluids in the Emergent Treatment of Pediatric Migraine
The goal of this clinical trial is to compare intravenous (IV) fluids in pediatric patients with migraine. The main questions it aims to answer are: * Does a large amount of fluids (bolus) improve pain * Does a large amount of fluids (bolus) reduce admissions to the hospital for migraine Participants will be asked to report their pain and have vital signs checked every 30 minutes for two hours. Researchers will compare a large amount of fluids (bolus) to a small amount (half maintenance) to see if there is a difference in pain improvement.
Patients will be randomized to one of two treatment groups. The intervention group will receive a 20 mL/kg bolus of normal saline (with a maximum of 1L), given over one hour. The control group will receive normal saline at half maintenance (with a maximum of 50mL/hr) over one hour. Both groups will receive: * ketoralac (Toradol), 0.5mg/kg, with a maximum of 30mg * diphenhydramine(Benadryl), 0.5mg/kg, with a maximum of 25mg * prochlorperazine(Compazine), 0.15mg/kg, with a maximum of 10mg Pain score, heart rate, and blood pressure will be monitored every 30 minutes from the start of the medications/fluids being started, for a period of two hours. Pain will be recorded using a 100mm visual analog scale.
Age
5 - 21 years
Sex
ALL
Healthy Volunteers
Yes
Dayton Children's Hosptial
Dayton, Ohio, United States
Start Date
June 27, 2023
Primary Completion Date
June 1, 2025
Completion Date
June 1, 2025
Last Updated
December 26, 2023
134
ESTIMATED participants
1/2 maintenance fluids
OTHER
Ketorolac
DRUG
Diphenhydramine
DRUG
Prochlorperazine
DRUG
bolus
OTHER
Lead Sponsor
Dayton Children's Hospital
NCT06641466
NCT07018713
NCT04715685
Data Source & Attribution
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