Study of MK-6552 in Participants With Narcolepsy Type 1 (MK-6552-004)

Exclusion Criteria

• •Has history of or current hypertension
• •Has underlying cardiovascular or cerebrovascular conditions in which an acute rise in blood pressure would pose a clinical concern, including but nor limited to aneurysms or arteriovenous malformations
• •Has a history of renal or hepatic impairment
• •Has a history of cardiac ischemia or cerebral ischemia including but not limited to history of stroke, transient ischemic attack, or transient global amnesia
• •Based on clinical interview and responses on the Columbia-Suicide Severity Rating Scale, is at imminent risk of self-harm or of harm to others in the opinion of the investigator
• •Mentally or legally incapacitated, has significant emotional problems at the time of prestudy (screening) visit or expected during the conduct of the study or has a history of clinically significant psychiatric disorder of the last 5 years
• •History of cancer (malignancy)
• •Has a history of any of the following sleep disorders: obstructive sleep apnea (OSA) defined as an Apnea Hypopnea Index \> 15 per hour per the American Academy of Sleep Medicine alternate criteria, primary insomnia (within the past 6 months), circadian rhythm sleep disorder, shift work sleep disorder (within the past 6 months), clinically significant parasomnia at the discretion of the investigator
• •Has a history of seizure disorder, clinically significant head trauma, or past invasive intracranial surgery or clinically significant dementia
• •Positive test(s) for Hepatitis B surface antigen, hepatitis C antibodies, or human immunodeficiency virus