ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)

Exclusion Criteria

• •Current smoker or regular use of nicotine containing products and/or cannabis
• •Heavy alcohol use (≥2 drinks/d for females, ≥3 drinks/d for males) or drug use
• •Known cognitive impairments or h/o stroke
• •Type 2 diabetes (known diagnosis or by screening A1c (≥6.5%))
• •Medical conditions (chronic diseases, cancer, MS) or labs limiting ability to participate
• •Females: currently pregnant (or 6-months postpartum of full-term pregnancy) and/or current breastfeeding
• •Use of medications with significant effects on appetite (e.g., weight loss medications, atypical antipsychotics, stimulants) and/or chronic use of anticoagulants
• •History of bariatric surgery
• •History of eating disorder
• •Current participation in a formal weight loss program
• •Prior or current participation in a research study involving weight loss
• •Weight-reduced by \>10% within past year
• •Weight \> 330 pounds (MRI limit)
• •Allergy or intolerance to or unwillingness to consume study foods provided at visit
• •MRI contraindication (e.g., implanted metal, claustrophobia)
• •Do not have a phone compatible with activity tracker or access to videoconferencing platform that will be used for the dietary intervention or other appropriate technology needed to complete study procedures
• •Any condition(s) found by the study team and confirmed with the PI(s) that make it unsafe to participate