Ilofotase Alfa for Prevention of Renal Damage After Cardiac Surgery

Inclusion Criteria

• •1. Age ≥18 years
• •2. Planned for one of the following types of open chest cardiovascular surgery with the use of cardiopulmonary bypass pump (CPB):
• •1. 1\. combined valve and CABG surgery; 2. aortic valve plus aortic root and/or ascending aorta (excluding aortic arch)
• •2. CABG with 3 or more distal anastomoses
• •3. Screening eGFR ≥25 mL/min/1.73m2 and ≤65 mL/min/1.73m2
• •4. Female patients of childbearing potential agreeing to use effective contraception within IP treatment and 14 days thereafter
• •Post-menopausal females do not require contraception during the trial.
• •5. Male patients agreeing to refrain from donating sperm, use a male condom when having sexual intercourse and in case their partner is of childbearing potential they must agree to use adequate and effective contraception method (see inclusion criterion 4) within IP treatment and 14 days thereafter