Trial of Ovarian Vein and Pelvic Vein Embolization in Women With Chronic Pelvic Pain and Pelvic Varices

Exclusion Criteria

• •Female \<18 years of age
• •Pregnancy (positive pregnancy test)
• •Female subject who plans to become pregnant during study period
• •Female subject who is actively breastfeeding
• •Patient who is post-menopausal or anovulatory with hormone suppression
• •History of prior hysterectomy
• •Prior ovarian vein embolization or ovarian vein ligation
• •Inability to tolerate endovascular procedure due to acute illness or general health
• •Planned simultaneous treatment with nerve blocks during the duration of the study
• •Laparoscopy or planned surgical intervention during the duration of the study
• •Known allergy to sclerosant, coil, stent or catheter components including nickel allergy
• •Any iliac vein stenosis determined identified by the investigator on pelvic DUS, CT venogram, and/or Catheter Venography and deemed significant for exclusion by study patient review committee.
• •Any renal vein stenosis with resultant renal hilar varices/collaterals and lumbar collaterals identified by the investigator on pelvic DUS, CT venogram, and/or Diagnostic Venography and deemed significant for exclusion by study patient review committee.
• •Presence of isolated extra-pelvic vulvar and/or lower extremity varices without intrabdominal pelvic varices. Primary S3 categorization study exclusion.
• •Serious medical conditions that might preclude full participation in the study to the desired endpoint (e.g., uncontrolled diabetes, malignancy, COPD, MI, CHF, etc.)
• •Severe allergy to iodinated or gadolinium-based contrast refractory to steroid premedication
• •Severe renal impairment (on chronic dialysis or estimated GFR \<30 mL/min)
• •Hemoglobin \<8.0 g/dL, uncorrectable INR \>3.0 or platelet count \<75,000/microliter
• •Inability to provide informed consent or to comply with study assessments
• •Post thrombotic IVC, iliac or ovarian vein changes