Regenerative Treatment of Peri-implantitis

Exclusion Criteria

• •A clearly mal-positioned dental implant
• •Significant interproximal horizontal bone loss (more than 50% of implant fixture length)
• •A mobile dental implant
• •Presence of uncontrolled or untreated periodontal disease
• •More than 2 weeks usage of antibiotics in the past two months
• •Subjects taking medications known to modify bone metabolism or those that can interfere with the normal wound healing (such as bisphosphonates, corticosteroids, hormone replacement therapy, parathyroid hormone, denosumab, strontium ranelate, etc.), or those with uncontrolled systemic diseases or conditions that may similarly affect the patient's healing (osteoporosis, osteopenia, hyperparathyroidism, Paget's disease, uncontrolled diabetes (HBA1c \> 8)).
• •Pregnant subjects or individuals attempting to get pregnant (self-reported)
• •Subjects smoking more than 10 cigarettes a day, or those with a history of drug or alcohol abuse (self-reported)
• •Subjects unable to maintain adequate oral hygiene (O'Leary plaque index more than 50%) (O'Leary et al., 1972)
• •Any other contraindications for undergoing periodontal surgery