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RECRUITINGPhase 3NCT06150560

A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

Lead sponsor: Mayo Clinic•1 U.S. locations•View source on ClinicalTrials.gov

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Contacts

ACHD Research Program

CONTACT

(507) 293-2565 RSTACHDRESPRG@mayo.edu

Alexander Egbe, MBBS, MPH

CONTACT

(507) 284-2520 Egbe.Alexander@mayo.edu

Sponsors

Lead Sponsor

Mayo Clinic

Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•B/S1 hypertension
•SBP 100-139 average based on 3 office measurements.
•Age 18 or Older
•Previous COA Repair

Exclusion Criteria

•Currently on beta blocker (BB) therapy
•Pregnancy/lactating
•eGFR\<30
•Hyperkalemia (serum potassium \>5.5mmol/L)
•Severe Aortic or Mitral valve stenosis or regurgitation
•Epicardial CAD diagnosis
•Received antihypertensive medications within the past year

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: August 3, 2025Terms

Trial snapshot

StatusRECRUITING

PhasePHASE3

Enrollment120

Start dateApr 2024

Last updatedAug 3, 2025

Condition

Coarctation of Aorta High Blood Pressure

Locations shown

Mayo Clinic in Rochester

Rochester, Minnesota

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 3, 2025Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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