A Study to Test a Medicine (Fitusiran) for Preventing Bleeds in People With Severe Hemophilia Who Previously Received Preventive Treatment With Emicizumab

Exclusion Criteria

• •Participants are excluded from the study if any of the following criteria apply:
• •Known coexisting bleeding disorders
• •History of antiphospholipid antibody syndrome.
• •History of arterial or venous thromboembolism, atrial fibrillation, significant valvular disease, myocardial infarction, angina, transient ischemic attack, or stroke. Participants who have experienced thrombosis associated with indwelling venous access may be enrolled.
• •Presence of clinically significant liver disease
• •Current or prior participation in a fitusiran trial
• •Current or prior participation in a gene therapy trial
• •AT activity \<60% at Screening, as determined by central laboratory measurement
• •Coexisting thrombophilic disorder - Hepatitis C virus antibody positive, except participants who have negative Hepatitis C viral load and no evidence of cirrhosis
• •Presence of acute hepatitis, ie, hepatitis A, hepatitis E.
• •Presence of acute or chronic hepatitis B infection
• •Known to be HIV positive with CD4 count \<200 cells/μL.
• •Reduced renal function
• •The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.