A Phase 2 Trial of Foscenvivint in Liver Cirrhosis Patients Caused by HIV/HCV Co-infection With Hemophilia (OP-724-H201)

Inclusion Criteria

• •Hemophilia patients with liver cirrhosis caused by HIV/HCV co-infection that fall under the following 1) and 2):
• •1. Serum HIV-RNA positive or HIV antibody positive patients (maintaining HIV-RNA \< 200 copies/mL and CD4 positive T lymphocyte count \>= 200 cells/µL at screening).
• •2. Regarding HCV, patients who had passed \>= 12 months after achieving SVR at registration.
• •Patients with Child-Pugh classification A or B (Child-Pugh score 5-9).
• •Patients who meet at least one of 1) to 2) for diagnosis of liver cirrhosis:
• •1. Liver stiffness measurement by FibroScan is \>= 12.5 kPa (Fibrosis stage F4) at screening.
• •2. Abdominal CT scan shows changes in liver shape and/or portal hypertension.
• •Patients with Performance Status 0-2.