1. Diagnosed mental illness or cognitive impairment, or taking antipsychotic, sedative-hypnotic, or anxiolytic-depressant medications

2. Serious abnormalities of liver or kidney function.

3. Prior alcohol or drug abuse

4. Second or third degree atrioventricular block, severe sinus bradycardia (\<50 beats/min), sick sinus node syndrome, congenital heart disease, and other cardiac arrhythmias that severely affect hemodynamic stability

5. Grade 3 hypertension

6. Any disease of the head, such as cerebral infarcts, epilepsy, head trauma, etc.

7. Confirmed diagnosis of non-tumor-induced chronic ( ≥3 months) neuropathic pain

8. Inability to understand the meaning of the scale and complete the scoring.

9. Women preparing for pregnancy, pregnant women, or breastfeeding

10. Patients with myasthenia gravis

11. Respiratory function score ≥3

Clinical Study of Dexmedetomidine Administered Intranasally to Relieve Perioperative Anxiety and Depression in Patients With Colorectal Tumors

What this study is about