CETI-ANKLE: Cetilar®️ in Patients With Ankle Injury or Chronic Trauma to the Ankle

Exclusion Criteria

• •1. Patients who received intraarticular injection treatment into the painful area within 3 months prior to the first visit
• •2. Ankle surgery in the previous six months
• •3. Topical NSAIDs application during the treatment period
• •4. BMI \> 32
• •5. Systemic inflammatory diseases (e.g. fibromyalgia, etc.)
• •6. Progressive serious medical conditions (such as cancer, AIDS or end-stage renal disease)
• •7. Patients with major infections in the observation period
• •8. Renal diseases (serum creatinine concentration more than 1.2 times the upper limit of the normal range according to the central laboratory definition reference values)
• •9. Liver dysfunction (serum alanine or aspartate transaminase concentrations more than 1.5 times the upper limit of normal range)
• •10. Patients with serious heart-related diseases such as cardiac arrest, a history of cerebral infarction, or ischemic heart disease
• •11. Patients who received systemic steroid treatment within 1 month prior to their first visit
• •12. Diabetic foot
• •13. Pregnant or lactating women