A Study to Learn About the Study Medicine Called PF-07868489 in Healthy Adult People and in People With Pulmonary Arterial Hypertension

Exclusion Criteria

• •clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, infections or allergic disease.
• •smoking more than 10 cigarettes (or equivalent) per day or smoking history ≥10 pack-years.
• •Any medical or psychiatric condition or laboratory abnormality.
• •Stopped receiving pulmonary hypertension chronic general supportive therapy 90 days prior to Day 1.
• •Pulmonary capillary wedge pressure \> 15 mmHg on right heart catheterization (RHC) conducted during Screening.
• •History of severe allergic or anaphylactic reaction or hypersensitivity to recombinant proteins or excipients in investigational product.
• •Major surgery within 8 weeks prior to randomization.
• •Participants who smoke more than 10 cigarettes (or equivalent) per day or has a smoking history ≥10 pack-years.