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Efficacy and Safety of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema s.c. 2.4 mg/2.4 mg) Once-weekly Compared to Tirzepatide 15 mg s.c. Once-weekly in Participants With Obesity
This study will look at how well CagriSema compared to Tirzepatide helps people lower their body weight. CagriSema is a new investigational medicine developed by Novo Nordisk that combines Cagrilintide and Semaglutide. CagriSema is not yet being prescribed by doctors. Participant will get injections once a week throughout the treatment period. Participant will inject the study medicine under the skin with a pen injector in the thigh, stomach, or upper arm. After a first low dose, the study medicine will be gradually increased until reaching the planned dose (2.4 mg CagriSema or 15 mg Tirzepatide). The study will last for about one and a half year for each participant.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Univ of Alabama Birmingham
Birmingham, Alabama, United States
Chambliss Clinical Trials LLC
Montgomery, Alabama, United States
FDRC
Costa Mesa, California, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Univ of Colorado at Denver
Aurora, Colorado, United States
Yale University School Of Medicine
New Haven, Connecticut, United States
Northeast Research Institute
Fleming Island, Florida, United States
Jacksonville Ctr For Clin Res
Jacksonville, Florida, United States
South Broward Research LLC
Miramar, Florida, United States
Hope Clin Res & Wellness
Conyers, Georgia, United States
Start Date
November 27, 2023
Primary Completion Date
December 8, 2025
Completion Date
January 9, 2026
Last Updated
February 6, 2026
809
ACTUAL participants
Cagrilintide
DRUG
Semaglutide
DRUG
Tirzepatide
DRUG
Lead Sponsor
Novo Nordisk A/S
NCT01143454
NCT07472881
Data Source & Attribution
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