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COMPLETEDNANCT06131294

Efficacy Evaluation of Two Different Fluoride Applications

The goal of this clinical trial is to evaluate the remineralizing or preservative effect of two different fluoride-containing products. The main question aims to answer how the mineral content of the ...

Lead sponsor: Ivoclar Vivadent AG•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Ivoclar Vivadent AG

Collaborators

Istanbul Medipol University Hospital

Age

13 - 50 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•At least two active non-cavitated white spot lesions on buccal surfaces of anterior teeth or premolars (ICDAS code 1 and 2; Nyvad score 1) in two different quadrants.
•Age between 13 and 50 years
•No untreated caries lesions or periodontal disease
•No systematic disease or medication (such as antidepressants, antibiotics etc.) that affects salivary flow rate
•Subjects claimed regular brushing at least twice a day
•Subjects had to agree to keep the scheduled recall appointments for at least 1 year.

Exclusion Criteria

•Inactive non-cavitated lesions (Nyvad Score 4)
•Lesions with microcavity, cavitation, chipping or discoloration
•Lesions at buccal side of the molars
•Lesions adjacent to restoration
•Developmental white spot lesions such as enamel hypoplasia
•Pregnancy

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: October 23, 2025Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment23

Start dateFeb 2023

Last updatedOct 23, 2025

Condition

White Spot Lesion

Locations shown

Istanbul Medipo University

Istanbul, Esenler

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 23, 2025Data synced to Clareo: May 17, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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