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The Effects of Topical Cannabidiol on Paramedian Forehead Flap Scar Healing: A Split Scar Study (TOPSCAR)
The purpose of this study is to find out what effects (good and bad) that cannabidiol (CBD) has on scar healing and appearance in patients who have undergone paramedian forehead flap reconstruction.
The patient will be asked to apply a silicone patch to half of the scar and experimental ointment (CBD oil ointment) with silicone patch) to the other half of the scar on their forehead. They will be randomized to which half of the scar the ointment will be applied. Neither they nor their physician will choose which half of the scar will have the experimental ointment applied. Specific instructions will be given to the patient on how to apply each drug (the silicone patch to one segment of the scar and the CBD with silicone patch to the other segment of the scar). They will apply the treatments twice a day for 2 months and, at their follow-up appointments, complete two questionnaires about how the scar is healing. Photographs of the scars will be taken at each visit and will be evaluated to determine if there is an improved outcome in the appearance of the scar.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
Start Date
May 1, 2026
Primary Completion Date
July 1, 2027
Completion Date
July 1, 2028
Last Updated
March 5, 2026
22
ESTIMATED participants
Vantage Hemp CBD Isolate + Silicone patch
DRUG
Silicone patch
DRUG
Lead Sponsor
University of Oklahoma
Data Source & Attribution
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