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Effect of Varying Transcutaneous Spinal Cord Stimulation Parameters and Location on Lower Extremity Motor Responses and Comfort
The goal of this study is to understand how transcutaneous spinal cord stimulation (tSCS) waveform, modulation frequency, and stimulation location impact lower extremity muscle activation and participant comfort in adults without neurologic conditions.
Investigators will use a test-retest design comparing neurophysiologic measures while receiving various combinations of stimulation waveforms, modulation frequencies, and stimulation locations to determine the settings which lead to the highest participant tolerance with the lowest lower extremity resting motor thresholds (RMTs).
Age
18 - 75 years
Sex
ALL
Healthy Volunteers
Yes
Shirley Ryan AbilityLab
Chicago, Illinois, United States
Start Date
October 1, 2025
Primary Completion Date
December 31, 2027
Completion Date
December 31, 2028
Last Updated
April 13, 2025
50
ESTIMATED participants
Spinal motor evoked responses (sMERs)
DEVICE
Continuous stimulation tolerance
DEVICE
Lead Sponsor
Shirley Ryan AbilityLab
Data Source & Attribution
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