Study Comparing Chronic Beryllium Disease to Pulmonary Sarcoidosis

Inclusion Criteria

• •Age ≥ 18 years
• •Sufficiently documented medical record.
• •Informed patients who did not object to participating in the research, or for deceased patients, did not object to the use of their data.
• •Cases: Patients followed for confirmed chronic beryllium disease by expert teams based on the ATS 2014 criteria, i.e., a history of exposure to beryllium, positivity of two abnormal lymphocyte proliferation tests (LPT) in blood and/or an abnormal LPT in bronchoalveolar lavage, granuloma found in pulmonary biopsy associated by compatible clinical, radiological or spirometric abnormalities.
• •Controls: Patients followed for sarcoidosis according to the ATS/ERS/WASOG criteria, i.e., (i) a compatible presentation, (ii) the presence of non-necrotizing granulomatosis in one or more tissues (except Löfgren's syndrome or Heerfordt syndrome), (iii) and exclusion of alternative causes of granulomatous diseases with pulmonary parenchymal involvement on thoracic CT and/or chest radiography.
• •Controls: without occupational exposure to beryllium.