Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
The University of Texas Health Science Center, Houston
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients on Intermittent mandatory ventilation (IMV) for more than 72 hours
Patients infused Fentanyl or Hydromorphone for more than 72 hours
Patients with evidence of reversal of process that caused respiratory failure, adequate oxygenation (PaO2/fraction of inspired oxygen (FiO2)\>200; Positive end expiratory pressure (PEEP)≤8 and Ph≥7.2
Patients hemodynamically stable
Patients with a failed single or multiple attempts at spontaneous breathing trials
You may not be if
Patients with history of opioid drug abuse
Patients receiving schedule II narcotics on a chronic basis for longer than 6 months prior to ICU admission or on other analgesic infusions other than Fentanyl or Hydromorphone
Patients with cervical spinal cord injury or neuromuscular disease
Patients with end stage liver disease at ICU admission (ie, International normalized ratio ≥2and not taking warfarin and/or a total serum bilirubin ≥1.5 times above normal limits
Patients with prolonged QTc interval ≥500
Patients with prior history of cardiac conduction defects or sudden death
Patients with QTc increase of ≥60 milliseconds above the value of prior EKGs measured during current ICU admission
